1. Damage of an intestine wall. It is necessary to notice that wall damage happened in all layers (97.2%), which evidences transmural affection. However in 2.8% of cases changes were detected in mucous-submucous layer. At acute inflammatory process we detected affected lymph nodes of average chromogeneity (4-5 points on Fleindler’s scale) in paraintestinal fiber.
2. Ulcerous defects. Ulcerous defects were characterised by absence of an accurate differentiation of layers in 77.7% of cases, hyperchromogenic inclusions in submucous layer – in 32.3%, total affection of a mucous layer – in 14.4%. Wide and narrow defects of submucous layer with longitudinal orientation were revealed in 31.1% of cases only.
On the basis of the comparative analysis of Biophilia NLS-graphy results and pathomorphological researches we have developed a method of Biophilia NLS-diagnostics of intestines ulcerous affections. At inflammatory process in an intestine, both at Crohn’s disease, and at ulcerative colitis, we marked changes of intestinal wall structure and its chromogeneity. These researches were carried out in a small number of patients with Crohn’s disease. Kuznetsova T.G. et al. has described changes of intestinal wall structure in the form of affected hollow organ symptom, on the basis of which it is possible to carry out differential diagnostics of intestines diseases. We have also revealed other changes in an intestine wall, such as hyperchromogenic inclusions, total affection of a mucous layer, narrow and wide defects of submucous layer, and have proven that such signs are typical for ulcerous affection.
3. Presence of pathologically changed vessels. Biophilia NLS-angiography have shown expressed changes of intestine wall vessels in 52.6% of cases, in 17.9% – average expressiveness of changes, in 11.6% – minor changes, in 17.9% of patients affection of vessels was not identified. Severe changes of a vascular wall evidence activity of inflammatory process. We have also investigated quantitative characteristics of a bloodflow in an intestine wall at inflammatory process, such as an index of resistance and speed of a bloodflow, which were compared to the results of central haemodynamics. We have found mechanisms of bloodflow abnormalities in an intestine wall, depending on expressiveness of inflammatory process according to Biophilia NLS-graphy.
4. Presence infiltration, fistulas, strictures and perianal complications, diagnostics of which will not be given in this article.
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